Treatment and prognostic impact of transient leukemia in neonates with Down syndrome
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چکیده
منابع مشابه
Treatment and prognostic impact of transient leukemia in neonates with Down syndrome.
Approximately 10% of the neonates with Down syndrome (DS) exhibit a unique transient leukemia (TL). Though TL resolves spontaneously in most patients, early death and development of myeloid leukemia (ML-DS) may occur. Prognostic factors as well as treatment indication are currently uncertain. To resolve that issue, we prospectively collected clinical, biologic, and treatment data of 146 patient...
متن کاملThyroid functions of neonates with Down syndrome
BACKGROUND We aimed to evaluate thyroid functions and volumes and detect abnormalities in 80 neonates with Down syndrome. METHODS Data about free triiodothyronine, free thyroxine, thyroid stimulating hormone, thyroglobulin and urinary iodine levels, and ultrasonographic thyroid volume were collected. RESULTS Abnormal thyroid function tests were detected in 53.8% of the patients (n = 50) and...
متن کاملTransient myeloproliferative syndrome associated with Down syndrome.
production run with hydrogen peroxide and rinsed with deionized water. As moisture may remain in the less accessible points of the system (bends and filters), Kathon CG is added to the rinse water to ensure a completely sterile process. As a result of this finding, the company marketing the cream compensated the patient and changed the procedure for cleaning the machinery, replacing the Kathon ...
متن کاملGATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome.
Children with constitutional trisomy 21 (Down syndrome) have an approximately 500-fold increased risk of developing acute megakaryoblastic leukemia (AMKL), a form of acute myeloid leukemia. Unique to newborn infants with Down syndrome is a transient leukemia (TL), also referred to as transient myeloproliferative syndrome, that undergoes spontaneous remission in the majority of cases but in appr...
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ژورنال
عنوان ژورنال: Blood
سال: 2008
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2007-10-118810